CFTR and Cystic Fibrosis From Structure to Function【電子書籍】[ Carlos M. Farinha ]
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<p>This Brief is devoted to the CFTR protein and cystic fibrosis, and it provides an updated perspective of the genetic, functional and cellular processes involved in this conformational disorder. Starting with a historical perspective on cystic fibrosis and its clinical features, the author departs into an in-depth description of the biology of the CFTR protein, ending with a discussion on the latest approaches aimed at developing corrective therapies for cystic fibrosis.</p> <p>First the basic aspects of cystic fibrosis as a disorder are addressed, focusing on genetics and mutation prevalence. Then the CFTR protein is discussed in detail: its structure and classification within the ABC transporter superfamily, its biogenesis with membrane insertion and chaperone assisted folding, its glycosylation and how it regulates the endoplasmatic reticulum quality control mechanisms that assess CFTR folding status. Extra attention is given to post-ER trafficking and regulation of membrane stability and anchoring, and to CFTR functions. This is linked to the molecular mechanisms through which different CFTR mutations cause cystic fibrosis. Finally, the different efforts aiming at rescuing the basic defect, most of which aim at repairing CFTR dysfunction, are covered.</p> <p>Through this integrated perspective, readers will obtain a unique insight into this fascinating membrane-bound protein and its associated disease. This Brief appeals to an audience interested in human genetics, protein folding, protein trafficking and physiology.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。・・・楽天Kobo電子書籍ストア
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<p><em>2nd edition</em>: A complete guide to the growing phenomenon of internet-based music distribution and the art of downloading, with details of the programs, products and websites and what they can do for you.</p> <p>Using clear terms and concise language, Steve Levine's book is a one-stop resource for everybody interested in this new and exciting technology. Developing from the file-sharing culture of the internet, downloading music has become one of the biggest methods of distribution of the modern music industry, but what is it, and how does it all work? Written by an expert in the field, this comprehensive guide explains the basics, walks you through the essentials like iPOD and iTUNES, and will help you make informed choices when purchasing new music online.</p> <ul> <li>How does downloading work?</li> <li>What does iTUNES offer that other services don't?</li> <li>What kind of sound quality should I expect?</li> <li>How do I record my downloads onto CD?</li> <li>How much music can I fit on my iPOD?</li> <li>How can downloading enhance my own music productions?</li> </ul>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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<p>It is indeed ironical that in the absence of a complete knowledge of Pathophysiology, clinical cardiologists are left with no choice but to do the best they can to help the patient with the armamentarium of drugs at their disposal. But nothing could be further from truth than to treat the diagnosed end point of a disease process without a full understanding of its patho physiology. This point was eloquently made by Dr. Arnold Katz in his Presidential Address (Chapter 1) at the 8th Annual Meeting of the American Section of the International Society for Heart Research held in Winnipeg, Canada, July 8-11, 1986. This volume represents a part of the scientific proceedings of this Meeting. From a reading of this treatise it will become evident that discoveries of newer scientific facts as well as a better understanding of pathophysiology are continuously influencing/ improving our therapeutic approaches in modern medicine. In this book, latest biochemical, physiological and pharmacological findings on different experimental models such as Myocaridal hypertrophy, Hypertension and heart failure, Diabetes, Cardio myopathies and Cardiac function in shock are described by internationally recognised experts. Hopefully information presented here will provide another building block to the edifice of Science of Cardiology which we all are trying to create. Acknowledgements We are grateful to the following Agencies and Foundations for their generous financial support of the Symposium, which formed the basis of this book. A. Major Contributors: 1. Manitoba Heart Foundation 2. Sterling-Winthrop Research Institute 3. Squibb Canada, Inc.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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<p>This book constitutes the refereed proceedings of the workshops which complemented the 23rd Symposium on Formal Methods, FM 2019, held in Porto, Portugal, in October 2019. This volume presents the papers that have been accepted for the following workshops: Third Workshop on Practical Formal Verification for Software Dependability, AFFORD 2019; 8th International Symposium From Data to Models and Back, DataMod 2019; First Formal Methods for Autonomous Systems Workshop, FMAS 2019; First Workshop on Formal Methods for Blockchains, FMBC 2019; 8th International Workshop on Formal Methods for Interactive Systems, FMIS 2019; First History of Formal Methods Workshop, HFM 2019; 8th International Workshop on Numerical and Symbolic Abstract Domains, NSAD 2019; 9th International Workshop on Open Community Approaches to Education, Research and Technology, OpenCERT 2019; 17th Overture Workshop, Overture 2019; 19th Refinement Workshop, Refine 2019; First International Workshop on Reversibility in Programming, Languages, and Automata, RPLA 2019; 10th International Workshop on Static Analysis and Systems Biology, SASB 2019; and the 10th Workshop on Tools for Automatic Program Analysis, TAPAS 2019.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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<p><strong>?QUIERES MEJORAR TU VISTA Y DEJAR DE USAR LAS GAFAS CON EL M?TODO BATES Y EJERCICIOS QUE PUEDES HACER EN CUALQUIER MOMENTO DE FORMA NATURAL?</strong></p> <p>El estilo de vida actual, que nos obliga a hacer un uso excesivo de la vista de cerca (uso de ordenadores, televisi?n, m?viles, trabajo de oficina, lectura…), hace que muchas personas tengan frecuentemente problemas de visi?n como miop?a, astigmatismo, hipermetrop?a…</p> <p>Sin embargo, al igual que cualquier otra parte del cuerpo, el ojo puede ejercitarse para mejorar su rendimiento y recuperar calidad de visi?n, hasta el punto de poder dejar de usar las gafas. Esta teor?a fue desarrollada por el doctor William H. Bates, que ide? un m?todo para mejorar la vista con ejercicios oculares sencillos que puedes hacer en casa para recuperar visi?n progresivamente, y que adem?s ayudan a otras afecciones del ojo como el ojo seco, la presbicia o el p?rpado ca?do.</p> <p>Junto a la explicaci?n de este m?todo y descripci?n de sus ejercicios, este libro recopila los mejores h?bitos y consejos, as? como errores frecuentes en el uso de la vista, con los que conseguir?s una mejor calidad de visi?n de forma natural.</p> <p>En este libro descubrir?s:</p> <ul> <li>La historia y fundamento del m?todo del doctor Williams H. Bates para mejorar la vista de forma natural</li> <li>Los consejos para cuidar tu vista en tu d?a a d?a y de forma natural</li> <li>Una selecci?n de ejercicios para mejorar afecciones como la miop?a, astigmatismo o hipermetrop?a como el sunning o el palming</li> <li>C?mo solucionar el p?rpado ca?do con ejercicios oculares</li> <li>Los mejores consejos para mejorar y solucionar el ojo seco</li> <li>Los alimentos m?s adecuados para cuidar y mejorar tu visi?n</li> <li>C?mo prevenir y mejorar la presbicia</li> <li>H?bitos para cuidar tus ojos si trabajas frente a un ordenador o haces uso excesivo de pantallas</li> <li>Los ejercicios para mejorar los tics o el p?rpado tembloroso</li> <li>C?mo solucionar el problema de las moscas voladoras en el ojo</li> <li>Los mejores h?bitos para mejorar tu higiene visual diaria</li> <li>Los errores m?s frecuentes que perjudican a tu vista para que no los cometas</li> </ul> <p><strong>?Est?s a solo un paso de descubrir c?mo mejorar tu visi?n y empezar a disfrutar de una mejor calidad de vista de forma natural!</strong></p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。
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